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The show initially centers on seven characters: brothers Charlie and Alan Harper ; Jake Harper, the dimwitted son of Alan and his first ex-wife; Judith Harper-Melnick, Alan's first ex-wife, Herb's ex-wife, and Jake and Milly's mother; Rose, one of Charlie's previous one night stands who continuously stalks him; Evelyn Harper, Charlie and Alan's wealthy, five time widowed, bisexual mother, and Jake's grandmother; and last of all, Berta, Charlie's sharp-tongued housekeeper, who later joins the main cast starting with season two after playing a major recurring role throughout the first season. In season nine, the show is revamped when Charlie is struck and killed by a moving train. Walden Schmidt replaces him as the new owner of the beach house, a recently divorced internet billionaire. In season eleven, Jake moves to Japan and leaves the series, so to replace "the half-man", Charlie's long-lost-daughter moves into the beach house after looking for her late father. The show also features numerous supporting characters, each of whom plays a prominent role in a small group of episodes.

The X chromosome is one of the two sex chromosomes in humans the other is the Y chromosome. The sex chromosomes form one of the 23 pairs of human chromosomes in each cell. The X chromosome spans about million DNA building blocks base pairs and represents approximately 5 percent of the total DNA in cells. Each person normally has one pair of sex chromosomes in each cell. Females have two X chromosomes, while males have one X and one Y chromosome. Early in embryonic development in females, one of the two X chromosomes is randomly and permanently inactivated in cells other than egg cells. This phenomenon is called X-inactivation or lyonization.

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The video shows the cat being mauled to death by two aggressive dogs, apparently as a punishment by the owner. Boca Del Rio Massacre — On september 20, , gunmen from Los Matazetas working at the time under orders of the Sinaloa Cartel dumped the tortured bodies of 35 men and women along a city highway in Boca Del. Man burned to death inside giant oven, company accused of gross negligence.